This study analyzes the influence of education of parents, race and ethnicity, awareness regarding HPV and provider recommendation on HPV vaccine acceptability for their children. The study uses data and statistical tests to predict that all the above factors did play an important role in shaping the decision of parents regarding HPV vaccine. The Statistical Package for Social Services (SPSS) was utilized to analyze the 2007 California Health Interview Survey data using Chi Square statistics. The results of the study show that the influence of education of parents and race, ethnicity was significant in HPV vaccine decisions but the influence of provider recommendation and HPV awareness was found to be minimal. The findings of this study are valuable for providers, health care researchers and public health professionals who are responsible for providing health education to people.