Dissertation/Thesis Abstract

Evolution and Function of Drososphila melanogaster cis-regulatory Sequences
by Hardin, Aaron, Ph.D., University of California, Berkeley, 2013, 72; 3686312
Abstract (Summary)

In this work, I describe my doctoral work studying the regulation of transcription with both computational and experimental methods on the natural genetic variation in a population. This works integrates an investigation of the consequences of polymorphisms at three stages of gene regulation in the developing fly embryo: the diversity at cis-regulatory modules, the integration of transcription factor binding into changes in chromatin state and the effects of these inputs on the final phenotype of embryonic gene expression.

Indexing (document details)
Advisor: Eisen, Michael
Commitee: Bachtrog, Doris, Karpen, Gary, Pachter, Lior
School: University of California, Berkeley
Department: Molecular & Cell Biology
School Location: United States -- California
Source: DAI-B 76/08(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Genetics, Evolution and Development
Keywords: Chromatin, Drosophila, Gene regulation, Polymorphism, Transcription factor
Publication Number: 3686312
ISBN: 9781321630619
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