In this work, I describe my doctoral work studying the regulation of transcription with both computational and experimental methods on the natural genetic variation in a population. This works integrates an investigation of the consequences of polymorphisms at three stages of gene regulation in the developing fly embryo: the diversity at cis-regulatory modules, the integration of transcription factor binding into changes in chromatin state and the effects of these inputs on the final phenotype of embryonic gene expression.
|Commitee:||Bachtrog, Doris, Karpen, Gary, Pachter, Lior|
|School:||University of California, Berkeley|
|Department:||Molecular & Cell Biology|
|School Location:||United States -- California|
|Source:||DAI-B 76/08(E), Dissertation Abstracts International|
|Subjects:||Molecular biology, Genetics, Evolution and Development|
|Keywords:||Chromatin, Drosophila, Gene regulation, Polymorphism, Transcription factor|
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