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Evolution and Function of Drososphila melanogaster
cis-regulatory Sequences
by Hardin, Aaron, Ph.D., University of California, Berkeley, 2013, 72; 3686312
Abstract (Summary)
In this work, I describe my doctoral work studying the regulation of transcription with both computational and experimental methods on the natural genetic variation in a population. This works integrates an investigation of the consequences of polymorphisms at three stages of gene regulation in the developing fly embryo: the diversity at cis-regulatory modules, the integration of transcription factor binding into changes in chromatin state and the effects of these inputs on the final phenotype of embryonic gene expression.
| Advisor: | Eisen, Michael |
| Commitee: | Bachtrog, Doris, Karpen, Gary, Pachter, Lior |
| School: | University of California, Berkeley |
| Department: | Molecular & Cell Biology |
| School Location: | United States -- California |
| Source: | DAI-B 76/08(E), Dissertation Abstracts International |
| Source Type: | DISSERTATION |
| Subjects: | Molecular biology, Genetics, Evolution and Development |
| Keywords: | Chromatin, Drosophila, Gene regulation, Polymorphism, Transcription factor |
| Publication Number: | 3686312 |
| ISBN: | 9781321630619 |
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