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In this work, I describe my doctoral work studying the regulation of transcription with both computational and experimental methods on the natural genetic variation in a population. This works integrates an investigation of the consequences of polymorphisms at three stages of gene regulation in the developing fly embryo: the diversity at cis-regulatory modules, the integration of transcription factor binding into changes in chromatin state and the effects of these inputs on the final phenotype of embryonic gene expression.
Advisor: | Eisen, Michael |
Commitee: | Bachtrog, Doris, Karpen, Gary, Pachter, Lior |
School: | University of California, Berkeley |
Department: | Molecular & Cell Biology |
School Location: | United States -- California |
Source: | DAI-B 76/08(E), Dissertation Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Molecular biology, Genetics, Evolution and Development |
Keywords: | Chromatin, Drosophila, Gene regulation, Polymorphism, Transcription factor |
Publication Number: | 3686312 |
ISBN: | 978-1-321-63061-9 |