Dissertation/Thesis Abstract

Impact of the Serotonin Transporter Polymorphism on Emotion Identification in Healthy Older Adults
by Scott, Staci E., Ph.D., University of Missouri - Saint Louis, 2014, 55; 3670407
Abstract (Summary)

Older adults exhibit reduced accuracy and efficiency for identifying facial emotion expressions yet it is unclear how genetic or cognitive variables influence these findings. This study examined the impact of serotonin transporter polymorphism 5-HTTLPR on patterns of explicit emotion identification accuracy and reaction time (RT) in healthy older adults. The impact of 5-HTTLPR on measures of processing speed, attention, and executive function as well as correlations between cognitive measures and emotion identification measures were also examined.

Methods:Forty-one individuals over the age of 50 were genotyped for bi-allelic and tri-allelic variants of 5-HTTLPR and administered an emotion recognition paradigm and tests of cognitive function.

Results: Results indicated that individuals carrying low expressing S alleles were significantly slower when identifying expressions of emotion, particularly fear and disgust. A similar pattern of results for fear and disgust was revealed for low expressing S and LG carriers, but these findings were not held after adjustment for multiple comparisons. RTs for happy and neutral faces were correlated with performance on measures of processing speed, attention, and executive function in low expression groups, but these findings were not held after adjustment for multiple comparisons.

Conclusions: Overall, this study suggests that possession of low-expressing genetic variants of 5-HTTLPR is associated with diminished emotion identification RT performance among healthy older adults.

Indexing (document details)
Advisor: Paul, Robert H.
Commitee: Bassi, Carl, Griffin, Michael, Welcome, Suzanne
School: University of Missouri - Saint Louis
Department: Psychology
School Location: United States -- Missouri
Source: DAI-B 76/05(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Neurosciences, Gerontology, Cognitive psychology
Keywords: Cognitive, Emotion recognition, Older adult, Serotonin transporter
Publication Number: 3670407
ISBN: 9781321468922
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