Acid mine drainage (AMD) has historically degraded surface and subsurface waters throughout the world. AMD largely has gone untreated up until the past few decades and the number of point sources of AMD grew faster than those that were treated. As a result, identifying the source and prioritizing sites to treat for AMD have consumed much of the resources involved with AMD remediation. This study applies a methodology of identifying and prioritizing AMD through a watershed approach within the Big Muddy River Watershed. This methodology was taken from a larger developed methodology laid out by an interagency taskforce that included the U.S. Department of the Interior agencies of the Bureau of Land Management (BLM), National Park Service (NPS), and U.S. Geological Survey (USGS), the U.S. Department of Agriculture (USDA) agency of the Forest Service (USFS), and the U.S. Environmental Protection Agency (USEPA). In addition to identification and prioritization of AMD sites, potential remedial measures are evaluated and recommended.