Dissertation/Thesis Abstract

Identification of candidate genes involved in fin/limb development and evolution using bioinformatic methods
by Mastick, Kellen J., M.S., University of South Dakota, 2014, 124; 1566765
Abstract (Summary)

Key to understanding the transition that vertebrates made from water to land is determining the developmental and genomic bases for the changes. New bioinformatic tools provide an opportunity to automate the discovery, broaden the number of, and provide an evidence-based ranking for potential candidate genes. I sought to explore this potential for the fin/limb transition, using the substantial genetic and phenotypic data available in model organism databases. Model organism data was used to hypothesize candidate genes for the fin/limb transition. In addition, 131 fin/limb candidate genes from the literature were extracted and used as a basis for comparison with candidates from the model organism databases. Additionally, seven genes specific to limb and 24 genes specific to fin were identified as future fin/limb transition candidates.

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Indexing (document details)
Advisor: Mabee, Paula
Commitee: Barakat, Abdelali, Lushbough, Carol, Porter, Megan
School: University of South Dakota
Department: Biology
School Location: United States -- South Dakota
Source: MAI 53/06M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Evolution and Development, Bioinformatics
Keywords: Vertebrates
Publication Number: 1566765
ISBN: 978-1-321-25609-3
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