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Dissertation/Thesis Abstract

Highly stabilized gadolinium chelates functionalized on metal nanoparticles as magnetic resonance imaging contrast agent
by Siddiqui, Talha S., Ph.D., New York University, 2014, 192; 3638474
Abstract (Summary)

Magnetic resonance imaging (MRI) is a non-invasive method for imaging and diagnosing tissue damage, organ function and the vascular system. Magnevist™ a complex of diethylenetriaminepentaacetic acid (DTPA) and Gd3+ is a clinically approved contrast agent for MRI. A derivative of DTPA was formed by the addition of two cysteine groups (DTPA-L-Cys) through amide linkage. The Gd complex of this ligand bonds with the silver surfaces through the cysteine thiols. GdDTPA-L-Cys was bound to ∼10nm diameter Ag nanoparticles for use as a multifunctional MRI contrast agent. The ligand and complex were characterized by 1H and 13C NMR, ESI-MS and IR spectroscopy. The silver construct was characterized by TEM, TGA and UV-Vis absorption spectra. The per metal complex r1 relaxivity of GdDTPA-L-Cys{Ag} greater than that of Magnavist™ with the same molarity for both compounds.

The synthesis of a DTPA derivative is described that allows it to bind to silver or gold nanoparticles through a single thiol linkage (DTPASH). The resulting Gd complex, GdDTPASH, was bound to Ag nanoparticles to create a single monolayer on the surface. The construct was further stabilized in buffered solution with the addition of a thiolated PEG chain. The highly stabilized nanoparticle construct delivers a high payload of Gd compelex and is an effective T1 brightening agent. The production of this type of construct opens the way for engineered multimodal MRI contrast agents.

Indexing (document details)
Advisor: Walters, Marc A.
Commitee: Jerschow, Alexej, Mahal, Lara, Weck, Marcus, Zaim-Wadghiri, Youssef
School: New York University
Department: Chemistry
School Location: United States -- New York
Source: DAI-B 76/02(E), Dissertation Abstracts International
Subjects: Organic chemistry, Nanoscience
Keywords: Contrast agent, GDDTPA, Magnetic resonance imaging, Multivalent, Nanoparticle, Silver
Publication Number: 3638474
ISBN: 978-1-321-22092-6
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