The purpose of this research is to synthesize an inhibitor that can block nitric oxide from being produced. Nitric oxide facilitates tumor growth at increased concentrations. An inhibitor can be synthesized to inactivate DDAH in order to prevent the conversion of asymmetric dimethylarginine, ADMA, to citrulline and dimethylamine. An increase in concentration of ADMA blocks the nitric oxide synthase and stops the production of nitric oxide. Efforts toward the synthesis of a DDAH-1 inactivator are reported.
This thesis also reports progress toward the synthesis of a sensor that can bind to phosphates in an effort to identify and quantify phosphorylated proteins. The ligand, 4,4'-(bisalkylguanidinium)-2,2'-bipyridine, has been synthesized for incorporation into the photoactive tris(2,2'-bipyridine) ruthenium(II) complex. The successful completion of two steps in this synthesis are reported.
|Advisor:||Dixon, Robert P., Miller, Lynne A.|
|Commitee:||Jones, Myron W., Shaw, Michael J.|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 53/04M(E), Masters Abstracts International|
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