Dissertation/Thesis Abstract

Regional cerebral hemodynamic responses to hypoxia in humans using MRI and NIRS
by Borzage, Matthew Thomas, Ph.D., University of Southern California, 2014, 195; 3628123
Abstract (Summary)

The primary goal of my thesis was to address my hypothesis that: there is preferential perfusion of the hindbrain regions, controlling autonomic function. To test this hypothesis I developed a system for delivering hypoxic challenges to volunteers while they were in the MRI. I developed NIRS protocols that allowed monitoring of the cerebellum. And I developed MRI methods that allowed for PC MRI to be used to monitor flow to the forebrain and hindbrain. Finally I combined these elements to investigate how the brain would react to hypoxia. Ultimately neither NIRS nor MRI detected systematic differences between the forebrain and hindbrain response to hypoxia but the developed methods are available for future studies that aim to explore the hemodynamic response in the developing brain or in adults with pathological conditions.

Indexing (document details)
Advisor: Khoo, Michael
Commitee: Bluml, Stefan, Seri, Istvan, Wood, John
School: University of Southern California
Department: Biomedical Engineering
School Location: United States -- California
Source: DAI-B 75/11(E), Dissertation Abstracts International
Subjects: Biomedical engineering, Medical imaging, Physiology
Keywords: Cerebellum, Forebrain, Hemodynamics, Hypoxia, MRI, NIRS
Publication Number: 3628123
ISBN: 978-1-321-03653-4
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