Dissertation/Thesis Abstract

Localization of Francisella pathogenicity island-encoded secreted proteins and their secretion system
by Hare, Rebekah Frances, Ph.D., University of Alaska Fairbanks, 2014, 162; 3624442
Abstract (Summary)

The Francisella pathogenicity island (FPI) is linked to virulence, intracellular growth, and a type VI secretion system. I hypothesize FPI encoded proteins are secreted during infection. Microscopy showed extracellularly localized FPI-encoded proteins. Extracellular-localization was reduced when expressed in the secretion mutant. These data suggest that FPI encoded proteins are secreted.

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Indexing (document details)
Advisor: Hueffer, Karsten
Commitee: O'Brien, Kristin, O'Hara, Todd, Taylor, Barbara
School: University of Alaska Fairbanks
Department: Biology and Wildlife
School Location: United States -- Alaska
Source: DAI-B 75/10(E), Dissertation Abstracts International
Subjects: Biology, Molecular biology, Microbiology
Keywords: Francisella pathogenicity island, Intracellular pathogens, Secreted proteins, Secretion system, Virulence genes
Publication Number: 3624442
ISBN: 9781303977961
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