The Francisella pathogenicity island (FPI) is linked to virulence, intracellular growth, and a type VI secretion system. I hypothesize FPI encoded proteins are secreted during infection. Microscopy showed extracellularly localized FPI-encoded proteins. Extracellular-localization was reduced when expressed in the secretion mutant. These data suggest that FPI encoded proteins are secreted.
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|Commitee:||O'Brien, Kristin, O'Hara, Todd, Taylor, Barbara|
|School:||University of Alaska Fairbanks|
|Department:||Biology and Wildlife|
|School Location:||United States -- Alaska|
|Source:||DAI-B 75/10(E), Dissertation Abstracts International|
|Subjects:||Biology, Molecular biology, Microbiology|
|Keywords:||Francisella pathogenicity island, Intracellular pathogens, Secreted proteins, Secretion system, Virulence genes|
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