Dissertation/Thesis Abstract

Regulation of S6KL during cell cycle progression
by Joseph, Alton J., M.S., California State University, Long Beach, 2014, 79; 1527714
Abstract (Summary)

mTOR (Mammalian Target ofRapamycin), PI3K (Phosphatidylinositol3-kinase) and MEK (Mitogen-activated protein kinase/ERK kinase) have been shown to be potent regulators ofS6Kl at G1 phase of the cell cycle. Research has been concentrated at the Gt phase to elucidate mTOR's role in cell growth and proliferation. Limited information is available on the activity ofmTOR, PI3K and ERKl/2 in cell cycle phases other than G1. Since we have observed that S6Kl is active in phases other than G1 our goal was to ascertain ifmTOR, PI3K or ERKl/2 have a role in regulating S6Kl during these cell cycle phases. Using cell cycle analysis and immunoblot analysis we have determined here that mTORand PI3K could play a role in regulating S6Kl at the G1/S transition iQ. the cell cycle but there is also indications that mTOR and PI3K are potentially involved in regulating S6Kl in the phases post-G1/S of the cell cycle, indicating a complex interaction between the kinases used to regulate S6Kl during the cell cycle. ERKl/2 is demonstrated to have limited involvement in the regulation of S6Kl during the cell cycle.

Indexing (document details)
Advisor: Lee-Fruman, Kay
Commitee:
School: California State University, Long Beach
Department: Biological Sciences
School Location: United States -- California
Source: MAI 52/06M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Biology, Microbiology
Keywords: Cell growth, Cell proliferation., Mammalian target of rapamycin, Mitogen-activated protein kinase, Phosphatidylinositol3-kinase
Publication Number: 1527714
ISBN: 9781303925696
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