Dissertation/Thesis Abstract

Analysis of Antioxidant Properties of Novel NMDA Receptor Antagonists and Radiosensitizers
by Nguyen, Quynh, M.S., University of the Sciences in Philadelphia, 2013, 59; 1527640
Abstract (Summary)

Our studies examined the antioxidant properties of two classes of compounds, N-methyl-D-Aspartate receptor (NMDAR) antagonists and radiosensitizers. Antioxidant properties can augment or attenuate desired functions of these compounds, which are their abilities to treat neurodegenerative diseases and cancers, respectively. We evaluated the capability of each compound to scavenge reactive oxygen species (ROS) using chemical methods, i.e. nitric oxide (NO) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical activity. We also examined the compounds using biological methods, i.e. cell culture studies utilizing human breast adenocarcinoma cell line, MCF-7 assays. The results showed insignificant decrease of free radical production for radiosensitizers and some of NMDAR antagonists. An NMDAR atagonist, (compound 9) showed a high percentage of antioxidant activity at 1 mM and cell viability at 10 ┬ÁM. Future studies can estimate ROS levels in cell culture, especially in neuronal cell lines. We can also screen more compounds for desired activities. iv

Indexing (document details)
Advisor: Adejare, Adeboye
Commitee: Bruist, Michael F., Li, Zhiyu, McEwen, Charles N
School: University of the Sciences in Philadelphia
Department: Biochemistry
School Location: United States -- Pennsylvania
Source: MAI 52/05M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Biochemistry
Keywords: Antagonists, Antioxideant properties, Breast cancer cell line, Free radicals, N-methyl-D-Aspartate receptor, Nitric oxide, Radiosensitizers, Reactive oxygen species
Publication Number: 1527640
ISBN: 9781303852671
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