The purpose of this study was twofold: (1) to adapt Croteau and Bergeron’s (2001) Information Technology Trilogy model and Luftman’s (2000) Strategic Alignment Maturity Model to the nonprofit sector and (2) to combine the adapted models with Miles and Snow’s (1978) strategy typology model and organizational performance measures based on McLaughlin and Jordan’s (2010) logic model to test a proposed model that examines the relationships between strategy typology, IT alignment maturity and organizational performance in nonprofit organizations. A cross-sectional survey design was implemented. One thousand, eight hundred and six organizations that had received grants from Indiana Community Foundations between 2009 and 2012 were selected to participate. Of those who were sent an electronic link to or paper version of the questionnaire, 244 provided responses, comprising a 14.5% response rate. Substantial missing data indicated the use of missing values analysis (MVA) and multiple imputation (MI) to obtain an estimated data set with which to test the model. Principal components analysis (PCA) and partial least squares path modeling (PLS-PM) confirmed that specific factors influence IT alignment maturity, with qualifications, and that for each of the four distinct strategy typologies Prospector, Analyzer, Defender and Reactor, there is a significantly different relationship between IT alignment maturity and organizational performance.