Dissertation/Thesis Abstract

Synthesis and Incorporation of Bisguanidine Ligands into a Ruthenium Metal Framework: Novel Receptors for Phosphate Monoester Recognition
by Whitney, Cameron, M.S., Southern Illinois University at Edwardsville, 2013, 82; 1551911
Abstract (Summary)

The purpose of this research is to develop a molecular sensor capable of binding phosphates with the ultimate goal to identify and quantify phosphorylated proteins. To this end the synthesis of two 4,4'-disubstituted-2,2'-bipyridine ligands was developed followed by the incorporation of these ligands into a photoactive tris(2,2'-bipyridine)ruthenium(II) complex. The two ligands will contain a cleft-like bisguanidine functionality believed to function as a phosphate recognition site. The successful synthesis of 4,4'-diacylguanidine-2,2'-bipyridine is reported along with the partial synthesis of 4,4'-dialkylguanidine-2,2'-bipyridine as well as the photoactive ruthenium complex

Indexing (document details)
Advisor: Dixon, Robert P.
Commitee: Patrick, Timothy, Shaw, Michael
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 52/04M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Analytical chemistry, Biochemistry, Organic chemistry
Keywords: Bipyridine, Guanadinium, Phosphate, Phosphorylation, Protein, Ruthenium
Publication Number: 1551911
ISBN: 9781303707506
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