The purpose of this research is to develop a molecular sensor capable of binding phosphates with the ultimate goal to identify and quantify phosphorylated proteins. To this end the synthesis of two 4,4'-disubstituted-2,2'-bipyridine ligands was developed followed by the incorporation of these ligands into a photoactive tris(2,2'-bipyridine)ruthenium(II) complex. The two ligands will contain a cleft-like bisguanidine functionality believed to function as a phosphate recognition site. The successful synthesis of 4,4'-diacylguanidine-2,2'-bipyridine is reported along with the partial synthesis of 4,4'-dialkylguanidine-2,2'-bipyridine as well as the photoactive ruthenium complex
|Advisor:||Dixon, Robert P.|
|Commitee:||Patrick, Timothy, Shaw, Michael|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 52/04M(E), Masters Abstracts International|
|Subjects:||Analytical chemistry, Biochemistry, Organic chemistry|
|Keywords:||Bipyridine, Guanadinium, Phosphate, Phosphorylation, Protein, Ruthenium|
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