Dissertation/Thesis Abstract

Exploring the molecular architecture of proteins: Method developments in structure prediction and design
by Chavan, Archana G., Ph.D., University of the Pacific, 2014, 324; 3609082
Abstract (Summary)

Proteins are molecular machines of life in the truest sense. Being the expressors of genotype, proteins have been a focus in structural biology. Since the first characterization and structure determination of protein molecule more than half a century ago1, our understanding of protein structure is improving only incrementally. While computational analysis and experimental techniques have helped scientist view the structural features of proteins, our concepts about protein folding remain at the level of simple hydrophobic interactions packing side-chain at the core of the protein. Furthermore, because the rate of genome sequencing is far more rapid than protein structure characterization, much more needs to be achieved in the field of structural biology. As a step in this direction, my dissertation research uses computational analysis and experimental techniques to elucidate the fine structural features of the tertiary packing in proteins. With these set of studies, the knowledge of the field of structural biology extends to the fine details of higher order protein structure.

Indexing (document details)
Advisor: Tsai, Jerry W.
Commitee: LiWang, Andy, LiWang, Patricia, McCallum, C. Michael, Tsai, Jerry W., Xue, Liang
School: University of the Pacific
Department: Pharmaceutical and Chemical Sciences
School Location: United States -- California
Source: DAI-B 75/05(E), Dissertation Abstracts International
Subjects: Biochemistry, Bioinformatics, Biophysics
Keywords: Casp, Cd, De novo sequence design, Expression, Helix-helix, Helix-sheet, Knob-socket model, Nmr, Protein design, Protein structure, Purification, Structure prediction, Tertiary packing
Publication Number: 3609082
ISBN: 978-1-303-67788-5
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