Dissertation/Thesis Abstract

Exploring the Contribution of the Anti-Oxidant SOD1 to the Adaptation of Cancer Cells to Oxidative Stress Conditions
by Hahn, Mary Kathryn, M.S., Icahn School of Medicine at Mount Sinai, 2013, 56; 1547950
Abstract (Summary)

Cancer cells are characterized by elevated ROS levels, which provide these cells with a distinct survival advantage, promoting proliferation, invasion, and resistance to apoptotic stimuli. In order to maintain ROS below a critical threshold that would otherwise result in death, cancer cells have appropriately adapted their anti-oxidative machinery. Here, I studied superoxide dismutase 1 (SOD1) as a potential contributor to cancer cell survival under conditions of high oxidative stress. I determined that SOD1 is up-regulated in a majority of cancer cells in which the activity of another dismutase, MnSOD, is reduced, and found evidence to suggest that SOD1 is essential for maintaining mitochondrial integrity in these cells. Additionally, I explored a possible mechanism by which mitochondrial SOD1 increases in cancer cells, and found evidence indicating that this is due to decreased MULAN levels. Last, I tested whether blocking SOD1 activity could sensitize cancer cells to chemotherapeutic treatment, and determined that additional mechanisms must exist to compensate for SOD1 activity loss.

Indexing (document details)
Advisor: Germain, Doris
Commitee: Germain, Doris, O'Connell, Matthew, Pfleger, Cathie
School: Icahn School of Medicine at Mount Sinai
Department: Cancer Biology
School Location: United States -- New York
Source: MAI 52/03M(E), Masters Abstracts International
Subjects: Biology, Biochemistry, Oncology
Keywords: Breast cancer, Mitochondria, Oxidative stress, Superoxide dismutase
Publication Number: 1547950
ISBN: 978-1-303-51194-3
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