We address outflow boundary conditions for blood flow modeling. In particular, we consider a variety of fundamental issues in the structured tree boundary condition. We provide a theoretical analysis of the numerical implementation of the structured tree, showing that it is sensible but must be performed with great care. We also perform analytical and numerical studies on the sensitivity of model output on the structured tree's defining geometrical parameters. The most important component of this dissertation is the derivation of the new, generalized structured tree boundary condition. Unlike the original structured tree condition, the generalized structured tree does not contain a temporal periodicity assumption and is thus applicable to a much broader class of blood flow simulations. We describe a numerical implementation of this new boundary condition and show that the original structured tree is in fact a rough approximation of the new, generalized condition.
We also investigate parameter selection for outflow boundary conditions, and attempt to determine a set of structured tree parameters that gives reasonable simulation results without requiring any calibration. We are successful in doing so for a simulation of the systemic arterial tree, but the same parameter set yields physiologically unreasonable results in simulations of the Circle of Willis. Finally, we investigate the extension of recently introduced PDF methods to smooth solutions of systems of hyperbolic balance laws subject to uncertain inputs. These methods, currently available only for scalar equations, would provide a powerful tool for quantifying uncertainty in predictions of blood flow and other phenomena governed by first order hyperbolic systems.
|Commitee:||Kelley, Tim, Olufsen, Mette, Smith, Ralph, Steele, Brooke|
|School:||North Carolina State University|
|School Location:||United States -- North Carolina|
|Source:||DAI-B 75/03(E), Dissertation Abstracts International|
|Subjects:||Applied Mathematics, Mathematics, Biomechanics|
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