Dissertation/Thesis Abstract

Disruption of the stress-response endocrine system in English sole of southern California: A study of potential interrenal mechanisms and environmental causes
by Causey, Dwight Ronald, M.S., California State University, Long Beach, 2013, 101; 1524182
Abstract (Summary)

In the present study, a form of endocrine disruption that impacts production of the important stress and metabolic hormone, cortisol, was confirmed in southern California English sole (Parophrys vetulus) and further characterized using cellular and molecular approaches. One of the key initial findings of the study was that the interrenal itself, when tested directly for its in vitro response to pituitary ACTH, was non-responsive in fish exhibiting the endocrine-disrupted phenotype. This pointed directly to a dysfunctional interrenal gland in the impacted fish. With this knowledge in hand, a proteomics-based approach was employed to screen for changes in tissue protein expression. This experimental effort resulted in the molecular identification of 107 proteins, 83 of which were from unique genes, and it elucidated a variety of changes in protein expression related to interrenal function and to exposure of the fish to specific kinds of anthropogenic environmental chemicals.

Indexing (document details)
Advisor: Kelley, Kevin M.
Commitee: Allen, Bengt J., Armstrong, Jeffrey L., Livingston, Brian
School: California State University, Long Beach
Department: Biology
School Location: United States -- California
Source: MAI 52/03M(E), Masters Abstracts International
Subjects: Endocrinology, Environmental Health, Physiology, Aquatic sciences
Keywords: California, Parophrys vetulus
Publication Number: 1524182
ISBN: 978-1-303-52159-1
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