In studies of two-dimensional (2D) stimulus-response compatibility (SRC), people respond faster and more accurately when compatibility is maintained along the horizontal dimension than the vertical dimension, an effect called right-left prevalence. Proponents of the salient features coding account have demonstrated that prevalence effects occur when one dimension within a control-display configuration is more salient than the other. The goal of the present study was to extend this account by investigating the role of control-display alignment (CDA) and its potential influence on dimensional salience. Participants completed two-choice 2D SRC tasks in four control-display configurations with a response panel centered above, below, left, and right of a projected display. As hypothesized, right-left prevalence was elicited using vertical CDA and top-bottom prevalence was elicited using horizontal CD A. The findings demonstrate that CDA influences the way people interact with controls and displays and should therefore be taken into account in future research and design.