Dissertation/Thesis Abstract

Loss of Post-natal Growth Hormone Receptor Signaling in Skeletal Muscle of Mice Does Not Affect Muscle Fiber Size and Response to Pathological Injury
by Buffin, Nicholas James, M.S., Icahn School of Medicine at Mount Sinai, 2013, 41; 1537185
Abstract (Summary)

In my thesis I investigated whether loss of growth hormone receptor (GHR) signaling affects post-natal skeletal muscle development and regenerative ability in adult male mice, and whether the effect is via insulin-like growth factor-1 receptor (IGF-1R) signaling. Mouse models were used that had a post-natal muscle-specific loss of GHR signaling (mGHRKO), insulin-like growth factor receptor/ insulin receptor (IGF-1R/IR) signaling (MKR ), and loss of both GHR and IGF-1R/IR signaling (mGHRKO/MKR). The loss of GHR signaling did not alter muscle igf-1 expression, fiber cross sectional area, fiber type proportions, or regenerative fusion ability. Further more, loss of IGF-1R/IR signaling decreased regenerative ability. In conclusion, my data suggests that GHR signaling does not play a role in post-natal skeletal muscle development or regenerative fusion ability, and that IGF-1R/IR signaling has an effect that is independent of direct GH effects on muscle, though may be affected by systemic GH/IGF-1 function.

Indexing (document details)
Advisor: LeRoith, Derek
Commitee: Krauss, Robert S., Mobbs, Charles V.
School: Icahn School of Medicine at Mount Sinai
Department: Biomedical Sciences
School Location: United States -- New York
Source: MAI 51/06M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Endocrinology
Keywords: Fiber fusion, Growth hormone, Igf-1, Mkr, Regeneration
Publication Number: 1537185
ISBN: 9781303073724
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