In my thesis I investigated whether loss of growth hormone receptor (GHR) signaling affects post-natal skeletal muscle development and regenerative ability in adult male mice, and whether the effect is via insulin-like growth factor-1 receptor (IGF-1R) signaling. Mouse models were used that had a post-natal muscle-specific loss of GHR signaling (mGHRKO), insulin-like growth factor receptor/ insulin receptor (IGF-1R/IR) signaling (MKR ), and loss of both GHR and IGF-1R/IR signaling (mGHRKO/MKR). The loss of GHR signaling did not alter muscle igf-1 expression, fiber cross sectional area, fiber type proportions, or regenerative fusion ability. Further more, loss of IGF-1R/IR signaling decreased regenerative ability. In conclusion, my data suggests that GHR signaling does not play a role in post-natal skeletal muscle development or regenerative fusion ability, and that IGF-1R/IR signaling has an effect that is independent of direct GH effects on muscle, though may be affected by systemic GH/IGF-1 function.
|Commitee:||Krauss, Robert S., Mobbs, Charles V.|
|School:||Icahn School of Medicine at Mount Sinai|
|School Location:||United States -- New York|
|Source:||MAI 51/06M(E), Masters Abstracts International|
|Keywords:||Fiber fusion, Growth hormone, Igf-1, Mkr, Regeneration|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be