The purpose of this study was to examine the relationship between acculturation and depression among Asian American immigrants in Los Angeles, California. A sample of 30 respondents was obtained from employees at a mental health agency. All respondents volunteered to participate in the study. The participants completed a self-administered questionnaire, which includes demographic questions, and surveys that measure acculturation and depression level. A quantitative design was used. Results indicated that there was no significant relationship between acculturation and depression level. The findings further indicated that there was no significant difference between acculturation and depression by gender. There was also no correlation between acculturation and depression and age, education, and income. Implications for future research and social work practice were addressed.