Dissertation/Thesis Abstract

Neuroprotection during anoxic stress in Drosophila melanogaster: The role of PKG pathway on protection of function and survival
by Meszaros, Raquel Benasayag, M.S., Florida Atlantic University, 2013, 76; 1523456
Abstract (Summary)

Anoxia is characterized by an absence of oxygen supply to a tissue (Dawson-Scully et al., 2010). Unlike humans, Drosophila melanogaster is an organism that can survive low oxygen levels for hours without showing any pathology (Lutz et al., 2003) Under anoxia, the fruit fly loses locomotive activity, resulting in an anoxic coma (Haddad et al., 1997). In this study we investigate the influence of five variables for anoxic tolerance in adult Drosophila: 1) anoxic environment (gas vs. drowning), 2) anoxia duration, 3) temperature (cold [3°C] or room temperature [21°C]), 4) age (young 2-9 days and old 35-39 days), and 5) PKG variation. Tolerance to anoxia is measured by the time of recovery and survival of the fruit fly from the anoxic coma. The results from this study show that short stress, low temperature, young age, and low PKG activity increased anoxic tolerance. Our findings will lay the foundation to investigate different variables, genes or pharmacological compounds that can modulate neuronal anoxic tolerance.

Indexing (document details)
Advisor: Dawson-Scully, Ken
Commitee: Milton, Sarah, Murphey, Rodney, Perry, Gary W., Prentice, Howard M., Rosson, Barry T.
School: Florida Atlantic University
Department: Biology
School Location: United States -- Florida
Source: MAI 52/01M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Neurosciences
Keywords:
Publication Number: 1523456
ISBN: 9781303227264
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