Dissertation/Thesis Abstract

There's something about glia: Post-injury radial glial response in the avian subventricular zone
by Vaughan, Rhiannon Brianne, M.A., California State University, Long Beach, 2013, 133; 1523322
Abstract (Summary)

Injury to the avian hippocampus increases stem cell activity in the subventricular zone (SVZ) indicating possible self-repair. Radial glia in the SVZ act as stem cells that mitotically divide forming new cells. Some differentiate into neurons; others develop a glial phenotype. Experiment 1 revealed an immediate post-injury response through comparison of the number of new cells in an intact versus injured brain. Experiment 2 was a post-injury analysis over time. A peak in new cells was observed at 72 hours, but no significant effect of time (2, 72, or 168 hours) was found. Qualitative observations in Experiment 3 revealed a radial glial response within 2 hours of injury, with an early peak and steady decline thereafter. Reactive astrocytes appeared 26 hours post-lesion, and increased thereafter. This study was the first to develop the procedure in birds, successfully double-label newly born radial glia, and show self-renewal of the stem cell layer.

Indexing (document details)
Advisor: Lee, Diane W.
Commitee: Green, Kenneth, Zavala, Arturo
School: California State University, Long Beach
Department: Psychology
School Location: United States -- California
Source: MAI 52/01M(E), Masters Abstracts International
Subjects: Neurobiology, Experimental psychology, Physiological psychology
Keywords: Hippocampus, Neurogenesis, Radial glia, Reactive astrocytes, Subventricular zone, Traumatic brain injury
Publication Number: 1523322
ISBN: 978-1-303-20890-4
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