Dissertation/Thesis Abstract

Plasma glucagon during development of insulin resistance among healthy individuals
by Laskey, Emma, M.S., California State University, Long Beach, 2013, 62; 1523059
Abstract (Summary)

The hormonal regulation of blood glucose homeostasis has a strong connection to obesity, and the insulin resistance (IR) that accompanies obesity. This thesis addresses the relationship between glucagon secretion, a key regulator of glucose homeostasis, and insulin resistance.

The purpose of this experimental study was to investigate the relationship between changes in fasting plasma glucagon and insulin sensitivity in a prospective model of nicotinic acid-induced IR in healthy adults (n = 11 ). After two weeks of nicotinic acid treatment, fasting insulin ( p = .002) and HOMA-IR increased significantly (p = .003), while fasting plasma glucose did not change, demonstrating development of IR but maintenance of glucose homeostasis. Fasting glucagon was decreased (p = .015). An inverse relationship was shown between changes in IR and changes in glucagon (p = .0275). Suppression of fasting plasma glucagon is a plausible homeostatic response to IR that maintains fasting glucose concentrations and thus homeostasis.

Indexing (document details)
Advisor: Lee, Jacqueline
Commitee: Ipp, Eli, Reiboldt, Wendy
School: California State University, Long Beach
Department: Nutritional Science
School Location: United States -- California
Source: MAI 52/01M(E), Masters Abstracts International
Subjects: Medicine, Nutrition
Publication Number: 1523059
ISBN: 9781303202636
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