The hormonal regulation of blood glucose homeostasis has a strong connection to obesity, and the insulin resistance (IR) that accompanies obesity. This thesis addresses the relationship between glucagon secretion, a key regulator of glucose homeostasis, and insulin resistance.
The purpose of this experimental study was to investigate the relationship between changes in fasting plasma glucagon and insulin sensitivity in a prospective model of nicotinic acid-induced IR in healthy adults (n = 11 ). After two weeks of nicotinic acid treatment, fasting insulin ( p = .002) and HOMA-IR increased significantly (p = .003), while fasting plasma glucose did not change, demonstrating development of IR but maintenance of glucose homeostasis. Fasting glucagon was decreased (p = .015). An inverse relationship was shown between changes in IR and changes in glucagon (p = .0275). Suppression of fasting plasma glucagon is a plausible homeostatic response to IR that maintains fasting glucose concentrations and thus homeostasis.
|Commitee:||Ipp, Eli, Reiboldt, Wendy|
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 52/01M(E), Masters Abstracts International|
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