The purpose of this study was to examine the efficacy of a gravity independent multi-mode exercise device (M-MED) and to evaluate a resistance (RE) and aerobic (AE) exercise protocol. Thirty-two participants (16 females and 16 males) aged 22 ± 0.4 years completed 5 weeks of training: RE, 4 sets of7 repetitions of squats 2 days a week and AE consisting of four, 4 minute high-intensity interval rowing at ∼90% V˙O₂max, 3 days per week. Three repetition maximum (3RM) leg press increased in both AE+RE and RE groups by +20% and ∼30% respectively. AE+RE V02max increased by 7.73 ± 1.99%. Cross sectional Area ofthe quadriceps femoris increased by 8.73 ± 3.94% in AE+RE and 16.5 ± 5.5% in RE. Isokinetic improvements were seen at all speeds in both groups. Aerobic capacity and strength gains indicate that the M-MED is effective in providing robust stimuli to musculoskeletal and cardiovascular systems.