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Dissertation/Thesis Abstract

Impact of physical activity in the prevention of colorectal cancer
by Barnes, Sarah A., M.S., University of South Carolina, 2013, 42; 1537616
Abstract (Summary)

This review evaluates the current understanding of research on the impact of physical activity in the prevention of colorectal cancer. Current biological mechanisms implicated in physical activity and colorectal cancer risk reduction are blood glucose regulation, insulin sensitivity, leptin and adiponectin profiles, inflammation as well as secreted protein acidic and rich in cysteine (SPARC), an exercise induced myokine. Recent literature indicates that 30-60 minutes of moderate to vigorous activity a day is effective against colorectal cancer development, and there is convincing evidence of aerobic exercise as differently beneficial in recruiting mechanisms identified as preventative against colorectal cancer. This article provides a critical review of the evidence-based literature concerning the benefits of physical activity in reducing the risk for colorectal cancer. Further well designed animal and clinical trials testing differing exercise protocols are recommended for future research to enable better understanding of the currently implicated mechanisms in colorectal cancer development.

Indexing (document details)
Advisor: Murphy, Angela
Commitee: Ai, Walden, Goldsmith, Edie
School: University of South Carolina
Department: Biomedical Science
School Location: United States -- South Carolina
Source: MAI 51/06M(E), Masters Abstracts International
Subjects: Medicine, Public health, Kinesiology
Keywords: Colorectal cancer, Physical activity, TNF-alpha
Publication Number: 1537616
ISBN: 978-1-303-09058-5
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