The purpose of this study was to analyze the cross-cultural and cross-time measurement invariance of Center for Epidemiological Studies Depression Scale (CES-D). The research data that were collected in 1994-1995 and 1996 respectively were from the National Longitudinal Study of Adolescent Health (Add Health). There were two steps that were used for analyzing the measurement invariance. First, Exploratory Factor Analysis (EFA) was used to analyze the dimension invariance (factor structure) for the Asian American and European American adolescents across two waves. Three-factor model was established for both groups across two waves. Second, Confirmatory Factor Analysis (CFA) was used to check the factor loading and threshold invariance of the items that were dimension invariant. The results showed that the 13-item three-factor CES-D was measurement invariant across the groups and across time. Nevertheless, new sample should be collected in order to implement the new 13 items as a depression screening method across groups.