The aim of the present systematic review of the literature was to identify which interventions had the best outcomes regarding burden and depression when utilized with caregivers of a family member diagnosed with dementia. A review of the literature that examined the variables that have been shown to affect the levels of burden and depression experienced by caregivers as well as the measures used to quantify their experiences was conducted. A comprehensive search for empirical research was conducted yielding 18 studies. Studies were included in this review if the sample size had at least 20 participants, published from 2002 to 2012 and examined burden, depression or both. Psychoeducational interventions tended to yield higher effect sizes in reducing burden while multidimensional interventions showed the most consistency in reducing depression. Despite the effects of current interventions being relatively small, caregivers have reported decreased feelings of depression and burden during short term follow-ups.