Dissertation/Thesis Abstract

Impact of Diabetes on Colorectal Cancer Outcomes
by Shah, Neel A., Ph.D., West Virginia University, 2012, 125; 3538202
Abstract (Summary)

Diabetes is one of the most common chronic comorbid condition seen in elderly CRC patients. Outcomes of CRC patients with diabetes specifically stage at diagnosis, emergency condition for CRC surgery, survival, and mortality have been insufficiently explored. The aims of the study were to investigate the association between diabetes and stage at diagnosis of CRC in elderly Medicare beneficiaries; to check the association of diabetes with presenting as an emergency condition for CRC surgery in the elderly and; to explore the effect of diabetes on survival of elderly Medicare beneficiaries with CRC. Using the SEER-Medicare data from 2003-2005, patients newly diagnosed with CRC were selected and divided into diabetic and nondiabetic cohorts. The two cohorts were compared in terms of stage at CRC diagnosis, emergency presentation for CRC surgery, and five year survival. Logistic regressions were used to check the association between diabetes and stage at diagnosis and emergency condition for CRC surgery. Survival analysis was employed compare time to death between diabetic and non-diabetic CRC patients. Covariates used in the study included the three most common comorbid conditions besides diabetes: coronary atherosclerosis, congestive heart failure, and chronic obstructive pulmonary disease, age, sex, race, tumor location, region in the country, patient location, and frequency of physician office visits. For survival analysis additional treatment variables – chemotherapy, radiation, and surgery were included. For stage at diagnosis of CRC, diabetes showed a significant inverse association (OR 0.92; 95% CI 0.85-1.00). On adding quintile of physician office visits this association was not significant. Odds of being diagnosed at a later stage was significantly associated with the least number of office visits (OR 2.13; 95% CI 1.86-2.44) as was having a proximal tumor (OR 1.40, 95% C 1.30-1.51) Although the odds of a diabetic patient being an emergency patient were lower than a non-diabetic, this was not statistically significant (OR 0.89; 95% CI 0.79-1.01) Mortality risk was significantly greater for diabetic CRC patients than nondiabetics (HR 1.15, 95% CI 1.09-1.20). Presenting emergently increased the risk of mortality (HR 1.61, 95% CI 1.54-1.68). Surgery for CRC reduced the risk of mortality (HR 0.41, 95% CI 0.39-0.43) and although in bivariate analyses patients who received chemotherapy were more likely to die, the hazard model showed a significant benefit associated with chemotherapy or radiation (HR 0.70, 95% CI 0.67-0.74). The worse terminal outcomes seen in diabetic CRC patients indicates the need for early and timely screening to prevent the disease or diagnosis at earlier stages.

Indexing (document details)
Advisor: Madhavan, S. Suresh
Commitee: Halverson, Joel, Pan, Xiaoyun Lucy, Petros, William P., Tworek, Cindy
School: West Virginia University
Department: Pharmaceutical Systems and Policy
School Location: United States -- West Virginia
Source: DAI-B 74/07(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Pharmacy sciences, Public health, Epidemiology
Keywords: Colorectal cancer, Diabetes, Elderly
Publication Number: 3538202
ISBN: 9781303004728
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