The purpose of this quantitative, descriptive/correlational project was to examine the relationship between the level of computer literacy, informatics training, nursing experience, and perceived competence in using computerized patient information systems (CPIS) and nursing resistance to using CPIS. The Nurse Computerized Patient Information System Questionnaire was used as the data collection instrument in this study because it addressed the research questions and hypotheses. Multiple linear regression analyses were used to investigate the correlation between computer literacy, informatics training, nursing experience, and self-reported competence as predictors of nurse resistance to CPIS use. In terms of the four major hypotheses of this project: (1) computer literacy was not shown to have a significant relationship to CPIS resistance, (2) participants who viewed themselves as having a higher level of competence tended to be less resistant to CPIS, (3) participants who used computers in more varied ways were less resistant to CPIS, and (4) participants who had received computer/informatics training through workshops or conferences tended to be less resistant to CPIS than those who had not. Other methods of training are unrelated to resistance.