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Dissertation/Thesis Abstract

Anatomical based breast phantoms and patient count rate based activity ratios for use with dedicated breast Positron Emission Tomography
by Saiz, Jessica Elaine, M.S., University of California, Davis, 2012, 56; 1519799
Abstract (Summary)

Dedicated breast PET scanners have been intensively investigated in recent years as their increased sensitivity and resolution are hypothesized to result in improvements in the early detection and determination of treatment response for breast cancer. However, there is currently no well-defined protocol for accurately evaluating their performance. This work aims to determine parameters for a set of phantoms for estimating count rate performances in pendant breast PET scanners.

A collection of 216 dedicated pendant breast CT images were divided into quartiles of overall volume (v), average radius ( r), and total length (l) of the breast. The 25th, 50th, and 75th quartile values of r and l were the parameters used for a set of 3 cylindrical phantoms. The cylindrical shape was chosen to remain consistent with the current NEMA whole body and small animal protocols. These cylinders, made out of high density polyethylene, are the small, medium, and large breast phantoms. For each phantom, the line source is placed at a radial offset of 4/5 of the phantom radius. Out-of-field of view activity is modeled using the NEMA-NU2 2007 scatter phantom. The parameters for each cylindrical phantom are as follows: Small, r = 4.2 cm, l = 7.1 cm; Medium, r = 4.8 cm, l = 9.0 cm; Large, r = 5.4 cm, l = 10.3 cm.

The activity ratios were determined by matching the patient prompts minus randoms (PR) rate in each breast phantom and the remaining patient randoms (R) rate in the whole body phantom. The ratio of activity in the whole body phantom to activity in the breast phantoms is as follows: Small, 105:1; Medium, 40:1; Large, 22:1.

Indexing (document details)
Advisor: Badawi, Ramsey D.
Commitee: Boone, John M., Cherry, Simon R.
School: University of California, Davis
Department: Biomedical Engineering
School Location: United States -- California
Source: MAI 51/03M(E), Masters Abstracts International
Subjects: Biomedical engineering, Medical imaging
Keywords: Breast pet/ct, Dedicated breast pet, Pet breast phantoms, Pet imaging
Publication Number: 1519799
ISBN: 978-1-267-66291-0
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