The purpose of this quantitative correlation study was to examine the predictors of user behavioral intention on the decision of oncology care providers to adopt or reject the clinical decision support system. The Unified Theory of Acceptance and Use of Technology (UTAUT) formed the foundation of the research model and survey instrument. The population consisted of oncology care providers affiliated with the Gynecologic Oncologic Group (GOG). The research indicated that the model was able to explain 32.4% of the variance in behavioral intention to adopt a CDS system. The results indicated a significance correlation between social influence and facilitating conditions on an oncology care provider’s behavioral intention to use a CDS system. The variables of performance expectancy and effort expectancy demonstrated no significant correlation with behavioral intention. Recommendations include creating an environment of positive social influence coupled with training and support programs designed to integrate CDS systems into the care provider’s clinical routine.