Dissertation/Thesis Abstract

The organization of proteins involved in synaptic plasticity
by Jacob, Amanda Louise, Ph.D., The University of North Carolina at Chapel Hill, 2012, 135; 3512642
Abstract (Summary)

The role that PSD organization plays in synaptic function and plasticity is only beginning to be understood. AMPARs play a well-established role in LTP; up-regulation of AMPARs within the postsynaptic density (PSD) is generally accepted to be the primary mechanism of NMDAR-dependent LTP. The function that AIDA-1 (Amyloid beta protein precursor intracellular domain-associated protein-1), a recently discovered component of the PSD, plays within synapses is less clear; however, in cultured hippocampal neurons, a portion of AIDA-1 translocates to the nucleus and increases downstream protein translation in response to NMDAR activation, Thus, experimental evidence suggests a role for AIDA-1 in synapse-to-nucleus signaling during NMDAR activation. My project uses electron microscopy and other histological techniques to determine the basal organization of AMPARs and AIDA-1 within the PSD. These data may provide better understanding of the roles these proteins play.

Indexing (document details)
Advisor: Weinberg, Richard J.
Commitee: Dudek, Serena M., Kash, Thomas L., Manis, Paul B., Philpot, Benjamin D.
School: The University of North Carolina at Chapel Hill
Department: Neurobiology
School Location: United States -- North Carolina
Source: DAI-B 73/11(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Neurosciences, Cellular biology
Keywords: Aida-1, Ampar, Glua1, Glua3, Proteins, Psd, Synaptic plasticity
Publication Number: 3512642
ISBN: 9781267418326
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