Dissertation/Thesis Abstract

Chronic HPA axis response to stress in temporomandibular disorder
by Lambert, Cynthia Ann, M.S., The University of North Carolina at Chapel Hill, 2012, 45; 1513048
Abstract (Summary)

Perceived stress is associated with temporomandibular disorder (TMD). We hypothesized that cortisol concentration, a biomarker of hypothalamic-pituitary-adrenal (HPA) axis function, was elevated in TMD cases relative to controls, and that perceived stress was positively correlated with cortisol concentration. In this case control study, TMD case status was determined by TMD Research Diagnostic Criteria. Adult participants (n=116) aged 18-59 years were recruited from within a 50-mile radius of the UNC at Chapel Hill. Cases (n=45) and controls (n=71) completed the 14-item Perceived Stress Scale using a reference interval of the past three months. Approximately 100 strands of hair were cut from the posterior vertex segment of their scalp and the most proximal portion was analyzed for cortisol concentration. TMD cases perceived higher stress than controls. Hair cortisol concentration was lower in TMD cases than controls. A weak negative relationship was determined between perceived stress and hair cortisol concentration.

Indexing (document details)
Advisor: Sanders, Anne E.
Commitee: Slade, Gary D., Wilder, Rebecca S.
School: The University of North Carolina at Chapel Hill
Department: Dentistry: Dental Hygiene
School Location: United States -- North Carolina
Source: MAI 50/06M, Masters Abstracts International
Subjects: Endocrinology, Dentistry
Keywords: Hormones, Hypothalamic pituitary regulating, Psychosocial, Temporomandibular joint disorders
Publication Number: 1513048
ISBN: 978-1-267-41848-7
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