Dissertation/Thesis Abstract

Synthesis of water soluble nanoparticles for biological applications
by Girau, Alexander L., M.S., Tulane University School of Science and Engineering, 2012, 58; 1512297
Abstract (Summary)

A synthetic route towards aqueous, luminescent, and non-toxic silicon nanoparticles for biological applications is described. This method utilizes High Energy Ball Milling (HEBM) in conjunction with subsequent surface reactions to form functionalized silicon nanoparticles. HEBM facilitates the manufacture of silicon nanoparticles by the mechanical comminution of crystalline silicon. The newly created reactive silicon sites allow a simultaneous surface functionalization to take place by the reactive organic liquid medium. These particles partition and solubilize into the organic media and can be isolated and tailored in an ad hoc fashion by subsequent surface reactions. After surface modification, the nanoparticles were shown to successfully complex with plasmid DNA via electrophoresis.

Indexing (document details)
Advisor: Mitchell, Brian S.
Commitee: Fink, Mark J., Godbey, W. T., Mitchell, Brian S.
School: Tulane University School of Science and Engineering
Department: Chemical and Biomolecular Engineering
School Location: United States -- Louisiana
Source: MAI 50/06M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Chemical engineering, Nanotechnology, Materials science
Keywords: Aqueous, Luminescent, Nanoparticle, Non-toxic, Photonics, Silicon
Publication Number: 1512297
ISBN: 978-1-267-39433-0
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