A synthetic route towards aqueous, luminescent, and non-toxic silicon nanoparticles for biological applications is described. This method utilizes High Energy Ball Milling (HEBM) in conjunction with subsequent surface reactions to form functionalized silicon nanoparticles. HEBM facilitates the manufacture of silicon nanoparticles by the mechanical comminution of crystalline silicon. The newly created reactive silicon sites allow a simultaneous surface functionalization to take place by the reactive organic liquid medium. These particles partition and solubilize into the organic media and can be isolated and tailored in an ad hoc fashion by subsequent surface reactions. After surface modification, the nanoparticles were shown to successfully complex with plasmid DNA via electrophoresis.
|Advisor:||Mitchell, Brian S.|
|Commitee:||Fink, Mark J., Godbey, W. T., Mitchell, Brian S.|
|School:||Tulane University School of Science and Engineering|
|Department:||Chemical and Biomolecular Engineering|
|School Location:||United States -- Louisiana|
|Source:||MAI 50/06M, Masters Abstracts International|
|Subjects:||Chemical engineering, Nanotechnology, Materials science|
|Keywords:||Aqueous, Luminescent, Nanoparticle, Non-toxic, Photonics, Silicon|
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