Type-2 diabetes mellitus (T2DM) levels within Native Hawaiian communities are one of the highest among the world's populations. No previous study has investigated relationships between genetic markers and risk phenotypes in Native Hawaiians nor factored in insights through oral transmission. Determination of the basis of T2DM susceptibility in Hawai'i is a two-perspective study: (1) a molecular approach through a screen of in-question single nucleotide polymorphism (SNP) markers for susceptibility to phenotypic risk factors of T2DM in a multiethnic sample of children from Hawai'i Island; and (2) an indigenous approach through oral communication with medical practitioners in O'ahu and Hawai'i Island communities who have been affected by T2DM. Presence of the susceptibility alleles in the ADRB2, GYS1, and SLC2A1 genes are consistent with phenotypic risk factors for T2DM. Six themes emerge through interviews, including diet, education, and accessibility, that contribute to the susceptibility and presence of T2DM in Hawai'i communities.
|Advisor:||Muir, Cedric C.|
|Commitee:||Aluli Meyer, Manulani, Brown, Daniel E.|
|School:||University of Hawai'i at Hilo|
|Department:||Tropical Conservation Biology & Environmental Science|
|School Location:||United States -- Hawaii|
|Source:||MAI 50/06M, Masters Abstracts International|
|Keywords:||Native Hawaiian, Single nucleotide polymorphisms, Type 2 diabetes|
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