The objective of this study was to evaluate the effects of orally administered soy-derived extracts on normal reproductive development in neonatal pigs as a model for infants on soy formula. Yorkshire-Landrace crossbred sows were randomly assigned to a lactating diet supplemented with either Novasoy 70 or without. Feed was top-dressed from d 100 of gestation until farrowing. Neonatal pigs (NPs) were weighed on post natal day (PND) six then randomly assigned to one of four treatments (1) control, (2) estradiol, (3) low, or (4) high genistein dose. This study demonstrates that oral exposure of NPs to estradiol but not genistein alters reproductive tract development and that this effect may be amplified from in utero exposure to sow diets with elevated concentrations of phytoestrogens. Thus, the neonatal pig may provide a useful model for assessing effects of dietary phytoestrogens on reproductive development in infants on soy-based formulas.
|Commitee:||Crenshaw, Mark A., Cunningham, Frederick L., Martin, James|
|School:||Mississippi State University|
|Department:||Animal and Dairy Sciences|
|School Location:||United States -- Mississippi|
|Source:||MAI 50/05M, Masters Abstracts International|
|Subjects:||Animal sciences, Physiology, Developmental biology|
|Keywords:||Estrogens, Genistein, Neonatal pigs, Phytoestrogens|
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