Meniere's disease is a clinical disorder of the inner ear defined by periodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. Cochlear Hydrops is similar to Meniere's but without vertigo. It is appropriate to mention Cochlear Hydrops because it may precede Meniere's disease.
Clinical care focuses on reducing the severity and frequency of vertigo because it is the most crippling symptom of Meniere's disease. Vertigo, tinnitus, and aural fullness are subjective; therefore many studies include hearing measurement as a secondary endpoint. Currently, there are no reliable metrics to describe hearing loss and fluctuations. The lack of information on hearing changes restricts its use as the primary endpoint in clinical trials. The purpose of this paper is to quantify both the probability of fluctuations (logistic regression) and the expected hearing losses over a period of time (longitudinal data analysis).
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 50/05M, Masters Abstracts International|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be